The lab is part of the Department of Physics at Loyola University Chicago and is located in Cudahy Science Hall. The research in the biophysics lab is conducted primarily by undergraduates from the Departments of Physics as well as the Departments of Biology and Chemistry. Our research focuses on understanding the structure and dynamics of non-helical DNA that arises during normal cellular processing but also from aberrant interactions that can lead to pathogenic states.
Using a custom, single-molecule fluorescence microscope, we explore the complex behavior of the DNA structures. The microscope detects signals from individual strands of DNA in real time with a spatial resolution as small as 1 nanometer and time resolution as fast as 10 milliseconds.